I've never bought an issue of Mental Floss, but boy am I going to when their December issue containing an interview with Bill Watterson is on stands.

Calvin and Hobbes is one of my absolute favorite works of sequential art. I love seeing comics adapted for the screen, both in animation and live action. I completely agree with Watterson regarding Calvin and Hobbes staying in its original medium and not succumbing to adaptation:

Years ago, you hadn’t quite dismissed the notion of animating the strip. Are you a fan of Pixar? Does their competency ever make the idea of animating your creations more palatable?

The visual sophistication of Pixar blows me away, but I have zero interest in animating Calvin and Hobbes. If you’ve ever compared a film to a novel it’s based on, you know the novel gets bludgeoned. It’s inevitable, because different media have different strengths and needs, and when you make a movie, the movie’s needs get served. As a comic strip, Calvin and Hobbes works exactly the way I intended it to. There’s no upside for me in adapting it.

I think there could be a good way to translate C&H to animation, but not as a franchise series of features or a TV show. If anything, animated shorts need to become something people can digest in ways other than Disney or Fox or WB (or whomever) slapping them in front of occasional mega-budget movies. It could be done well, but if Watterson isn't involved, it's just the same as The All-New, All-Different, Ted-Geisel-Free Lorax to me: wolves in sheep's clothing.