Multiversity Comics caught something in an interview in USA Today:

She-Hulk has a pedigree with the team since she has been a member of the Fantastic Four, plus she’d be Ben’s pick because she’s “the one person he knew he could never lick,” says Fraction, who writes Red She-Hulk in Defenders, which ends its run at issue 12 in November.

This is a shame, as I felt the book was getting a good footing, and the team dynamic could work in the ongoing and broader-than-ever Marvel U.