Nikki Finke just broke news that Sony has gotten Raimi and Tobey Maguire signed on for a 4th and apparently 5th Spider-Man outing. I wasn't a fan of the third one and my wife thought "they could have saved a bunch of starving people with that kind of budget," so I'm kind of mixed looking forward to the next.
Interesting to note that they say "once you find out who the villain is, you'll know who's playing it." So here are a couple off-the-top-of-my-head guesses:
Willem Dafoe as the Green Goblin (Norman Osborn has died & come back a million times, seems like)
James Franco as The Hobgoblin (another "comic book dead" guy)
Patrick Stewart as The Vulture (out on a limb here, and not very compelling)
Bruce Campbell as Mysterio (for chuckles)
The above are all possibilities, but it's got to be...Dylan Hunt as The Lizard. The hint made it too easy. The dramatic groundwork has been laid for this story already, and logically, if you knew the villain was The Lizard, you'd know Dylan Baker would be it.
Also they're still moving forward with the Julie Taymor-directed Broadway musical project, with U2's Bono & The Edge writing the score. Make of that what you will.